2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aldehyde Oxidase (AO)

Aldehyde Oxidase (AO)

Aldehyde Oxidase; AO

Aldehyde Oxidase is a soluble cytoplasmic molybdenum-containing enzyme that is mainly involved in the biotransformation of various drugs and xenobiotics. Aldehyde Oxidase has four isoforms (AOX1, AOX3, AOX3L1, and AOX4). Aldehyde Oxidase is mainly expressed by the liver, but is distributed widely in the lungs, kidneys, brain, and skin. Aldehyde Oxidase catalyzes oxidation and reduction reactions, among which the oxidation of aldehydes, nitro/nitroso compounds or N-heterocycles are more common. Aldehyde Oxidase affects drug metabolism, impacts drug interactions, and generates potential toxic metabolites. Aldehyde Oxidase could lead to liver damage (such as NAFLD), renal toxicity and amyotrophic lateral sclerosis (ALS)[1][2].

Aldehyde Oxidase (AO) Isoform Specific Products:

Aldehyde Oxidase (AO) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13735
    Quinacrine
    		Inhibitor 98.20%
    Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm).
    Quinacrine
  • HY-RS17631
    Aox1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Aox1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aox1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Aox1 Mouse Pre-designed siRNA Set A
    Aox1 Mouse Pre-designed siRNA Set A
Aldehyde Oxidase (AO) Isoform Comparison

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